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Without transparent pricing and fiduciary alignment, PBMs can generate significant hidden revenue on specialty drugs through rebate retention, specialty pharmacy steering and opaque distribution arrangements
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In general, most hydrophobic BAs are considered as FXR agonists, while hydrophilic non-12α-OH TMCA, UDCA, and T(G)UDCA serve as endogenous FXR antagonists 4,9,10
