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Collectively, these data indicate that GLP1R expression on CD8+TILs cells is scant, GIPR is undetectable, and agonism of GLP1R in CD8+ TILs is modestly immunosuppressive
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A post-hoc analysis of SURMOUNT-5 estimated a larger reduction in predicted 10-year cardiovascular risk with tirzepatide (23.7%) than semaglutide (13.6%), but these are modeled projections, not measured outcomes
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