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In the span of three months, Wegovy (injectable and oral) drove the most weight loss, followed by Ozempic and Rybelsus

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Important safety considerations include an increased risk of hypoglycemia when used with insulin or sulfonylureas, and a boxed warning about thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2)